Article
[Genetic instability of the feature of streptomycin resistance in Streptomyces erythraeus].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Dec 1990
Zavorotnaia S A, Fedorenko V A, Danilenko V N
Abstract excerpt
The feature of streptomycin resistance in S. erythraeus, a culture producing erythromycin, is genetically unstable. Mutants sensitive to 0.03 mg/ml of streptomycin are formed in the initial streptomycin resistant strains at a rate of 0.04 per cent. It was shown possible to perform step-by-step selection for increasing streptomycin resistance (from 0.2 to 15 mg/ml) in the mutants producing and not producing...
Topics
- Culture Media
- DNA, Bacterial
- Drug Resistance, Microbial
- Erythromycin
- In Vitro Techniques
- Microbial Sensitivity Tests
- Mutation
- Streptomyces
- Streptomycin