Article
[Isolation and characteristics of rifampicin-resistant mutants of Streptomyces erythraeus strain].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Dec 1990
Nastasiak I N, Fedorenko V A, Kirichenko N V, Danilenko V N
Abstract excerpt
Erythromycin-producing strains of S. erythraeus were characterized with respect to formation of spontaneous and induced rifampicin-resistant mutants. It was shown that the frequency of spontaneous rifampicin-resistant mutants formed by various strains amounted to 0.9.10(-8) = 9.1.10(-7). In some events the exposure to nitrosoguanidine increased the frequency of such mutants by 2 orders of magnitude. The...
Topics
- Culture Media
- Drug Resistance, Microbial
- In Vitro Techniques
- Microbial Sensitivity Tests
- Mutation
- Rifampin
- Streptomyces
