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Article

Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men

26 Aug 2010

Abstract excerpt

Physical inactivity is a risk factor for insulin resistance. We examined the effect of 9 days of bed rest on basal and insulin-stimulated expression of genes potentially involved in insulin action by applying hypothesis-generating microarray in parallel with candidate gene real-time PCR approaches in 20 healthy young men. Furthermore, we investigated whether bed rest affected DNA methylation in the promoter...

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PMID: 20739510
DOI: 10.1152/ajpendo.00590.2009

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