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Article

Evaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis.

Journal of pediatric orthopedics - 1 Sept 2010

Shyy William, Wang Kai, Gurnett Christina A, Dobbs Matthew B, Miller Nancy H, Wise Carol, Sheffield Val C, Morcuende Jose A

Abstract excerpt

BACKGROUND: Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity in children. Studies have shown low melatonin levels resulting from pinealectomy in chickens and mice result in the development scoliosis, whereas supplementation with melatonin after the pinealectomy prevented it. The mere characterization of low melatonin levels is not sufficient to explain the development of idiopathic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nuclear Receptor Subfamily 1, Group F, Member 1

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Source

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Identifiers

PMID: 20733416
DOI: 10.1097/BPO.0b013e3181e7902c
PMCID: PMC2928583

Genes

GPR50

Provenance

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Evaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis.PMID 20733416Read ↗

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