A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis.

doi:10.3390/ijms150916484

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Article

A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis.

International journal of molecular sciences - 18 Sept 2014

Man Gene Chi Wai, Wai Man Gene Chi, Wang William Wei Jun, Jun Wang William Wei, Yim Annie Po Yee, Yee Yim Annie Po, Wong Jack Ho, Ho Wong Jack, Ng Tzi Bun, Bun Ng Tzi, Lam Tsz Ping, Ping Lam Tsz, Lee Simon Kwong Man, Man Lee Simon Kwong, Ng Bobby Kin Wah, Wah Ng Bobby Kin, Wang Chi Chiu, Chiu Wang Chi, Qiu Yong, Yong Qiu, Cheng Chun Yiu, Yiu Cheng Jack Chun

Abstract excerpt

Adolescent idiopathic scoliosis (AIS) is a common orthopedic disorder of unknown etiology and pathogenesis. Melatonin and melatonin pathway dysfunction has been widely suspected to play an important role in the pathogenesis. Many different types of animal models have been developed to induce experimental scoliosis mimicking the pathoanatomical features of idiopathic scoliosis in human. The scoliosis deformity was...

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PMID: 25238413
DOI: 10.3390/ijms150916484
PMCID: PMC4200812

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