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Article

Characterization of a carcinogenesis rat model of ovarian preneoplasia and neoplasia.

Cancer research - 15 Nov 2004

Stewart Sherri L, Querec Troy D, Ochman Alexander R, Gruver Briana N, Bao Rudi, Babb James S, Wong Thang S, Koutroukides Theodoros, Pinnola Aaron D, Klein-Szanto Andres, Hamilton Thomas C, Patriotis Christos

Abstract excerpt

Animal models of ovarian cancer are crucial for understanding the pathogenesis of the disease and for testing new treatment strategies. A model of ovarian carcinogenesis in the rat was modified and improved to yield ovarian preneoplastic and neoplastic lesions that pathogenetically resemble human ovarian cancer. A significantly lower dose (2 to 5 mug per ovary) of 7,12-dimethylbenz(a)anthracene (DMBA) was applied...

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Identifiers

PMID: 15548682
DOI: 10.1158/0008-5472.CAN-04-1702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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