Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.

Cancer research - 1 Sept 2012

Prudent Renaud, Vassal-Stermann Emilie, Nguyen Chi-Hung, Pillet Catherine, Martinez Anne, Prunier Chloé, Barette Caroline, Soleilhac Emmanuelle, Filhol Odile, Beghin Anne, Valdameri Glaucio, Honoré Stéphane, Aci-Sèche Samia, Grierson David, Antonipillai Juliana, Li Rong, Di Pietro Attilio, Dumontet Charles, Braguer Diane, Florent Jean-Claude, Knapp Stefan, Bernard Ora, Lafanechère Laurence

Abstract excerpt

The emergence of tumor resistance to conventional microtubule-targeting drugs restricts their clinical use. Using a cell-based assay that recognizes microtubule polymerization status to screen for chemicals that interact with regulators of microtubule dynamics, we identified Pyr1, a cell permeabl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Lim Kinases

Share to Microtubules

Share to Protein Stability

Share to Tubulin

Share to Tubulin Modulators

Source

Identifiers

PMID: 22761334
DOI: 10.1158/0008-5472.CAN-11-3342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22761334-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.PMID 22761334Read ↗

LIM kinases: cofilin and beyondSemantic proximity Read ↗

ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A.Semantic proximity Read ↗

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.Semantic proximity Read ↗

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1Semantic proximity Read ↗

LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer.Semantic proximity Read ↗

Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule‐dependent mechanismSemantic proximity Read ↗

βI-tubulin mutations in the laulimalide/peloruside binding site mediate drug sensitivity by altering drug-tubulin interactions and microtubule stability.Semantic proximity Read ↗

The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells.Semantic proximity Read ↗

Azaindole derivatives are inhibitors of microtubule dynamics, with anti‐cancer and anti‐angiogenic activitiesSemantic proximity Read ↗

The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors.Semantic proximity Read ↗

Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.