Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism.

doi:10.1016/j.comppsych.2009.11.008

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Article

Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism.

Comprehensive psychiatry - 1 Jan 2000

Demetrovics Zsolt, Varga Gabor, Szekely Anna, Vereczkei Andrea, Csorba Jozsef, Balazs Hedvig, Hoffman Katalin, Sasvari-Szekely Maria, Barta Csaba

Abstract excerpt

BACKGROUND: Candidate genes of the dopaminergic system have been reported as key elements in shaping human temperament. Catechol-O-methyltransferase (COMT) plays a vital role in dopamine inactivation, and the Val(158)Met single nucleotide polymorphism (rs4680) in its gene has been recently associated with the Novelty Seeking (NS) temperament scale of the Temperament and Character Inventory in studies of healthy...

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PMID: 20728009
DOI: 10.1016/j.comppsych.2009.11.008

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COMT

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