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Article

Role of novelty seeking personality traits as mediator of the association between COMT and onset age of drug use in Chinese heroin dependent patients.

PloS one - 1 Jan 2011

Li Ting, Yu Shunying, Du Jiang, Chen Hanhui, Jiang Haifeng, Xu Ke, Fu Yingmei, Wang Dongxiang, Zhao Min

Abstract excerpt

BACKGROUND: Personality traits such as novelty seeking (NS) are associated with substance dependence but the mechanism underlying this association remains uncertain. Previous studies have focused on the role of the dopamine pathway. OBJECTIVE: Examine the relationships between allelic variants of the catechol-O-methyltransferase (COMT) gene, NS personality traits, and age of onset of drug use in heroin-dependent...

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Identifiers

PMID: 21857968
DOI: 10.1371/journal.pone.0022923
PMCID: PMC3157337

Genes

COMT

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