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Article

IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Jan 2011

Pollack Ian F, Hamilton Ronald L, Sobol Robert W, Nikiforova Marina N, Lyons-Weiler Maureen A, LaFramboise William A, Burger Peter C, Brat Daniel J, Rosenblum Marc K, Holmes Emiko J, Zhou Tianni, Jakacki Regina I

Abstract excerpt

PURPOSE: Recent studies have demonstrated a high frequency of IDH mutations in adult "secondary" malignant gliomas arising from preexisting lower grade lesions, often in young adults, but not in "primary" gliomas. Because pediatric malignant gliomas share some molecular features with adult secondary gliomas, we questioned whether a subset of these tumors also exhibited IDH mutations. EXPERIMENTAL DESIGN: We...

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Identifiers

PMID: 20725730
DOI: 10.1007/s00381-010-1264-1
PMCID: PMC3014378

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group.PMID 20725730Read ↗

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