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Article

Biphasic role of 4‐1BB in the regulation of mouse cytomegalovirus‐specific CD8<sup>+</sup> T cells

28 Jul 2010

Abstract excerpt

The initial requirement for the emergence of CMV-specific CD8(+) T cells is poorly understood. Mice deficient in the cosignaling TNF superfamily member, 4-1BB, surprisingly developed exaggerated early CD8(+) T-cell responses to mouse CMV (MCMV). CD8(+) T cells directed against acute MCMV epitopes were enhanced, demonstrating that 4-1BB naturally antagonizes these primary populations. Paradoxically,...

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PMID: 20722077
DOI: 10.1002/eji.200940256

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