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Article

SUMOylation negatively regulates transcriptional and oncogenic activities of MafA.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2010

Kanai Kenichi, Reza Hasan Mahmud, Kamitani Akiyo, Hamazaki Yuri, Han Song-iee, Yasuda Kunio, Kataoka Kohsuke

Abstract excerpt

Dysregulated expression of Maf proteins (namely c-Maf, MafA and MafB) leads to multiple myeloma in humans and oncogenic transformation of chicken embryonic fibroblasts. Maf proteins are transcriptional activators of tissue-specific gene expression and regulators of cell differentiation. For example, MafA is a critical regulator of crystallin genes and the lens differentiation program in chickens. In mammals, MafA...

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PMID: 20718938
DOI: 10.1111/j.1365-2443.2010.01431.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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