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Article

The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation.

The Journal of biological chemistry - 9 Jan 2009

Guo Shuangli, Burnette Ryan, Zhao Li, Vanderford Nathan L, Poitout Vincent, Hagman Derek K, Henderson Eva, Ozcan Sabire, Wadzinski Brian E, Stein Roland

Abstract excerpt

The level of the MafA transcription factor is regulated by a variety of effectors of beta cell function, including glucose, fatty acids, and insulin. Here, we show that phosphorylation at Ser(65) of mammalian MafA influences both protein stability and transactivation potential. Replacement of Ser...

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Identifiers

PMID: 19004825
DOI: 10.1074/jbc.M806314200
PMCID: PMC2613637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19004825-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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