Article
Re-evaluation of the role of STOX1 transcription factor in placental development and preeclampsia.
Journal of reproductive immunology - 1 Nov 2009
Rigourd Virginie, Chelbi Sonia, Chauvet Caroline, Rebourcet Régis, Barbaux Sandrine, Bessières Bettina, Mondon Françoise, Mignot Thérèse-Marie, Danan Jean-Louis, Vaiman Daniel
Abstract excerpt
Preeclampsia is a common disease of pregnancy, characterized by high blood pressure and proteinuria appearing from the second trimester of gestation. Preeclampsia has been shown to have a strong genetic component. In 2005 a positional cloning project led to the discovery of the STOX1 transcription factor, and mutations of this gene were proposed as causal for preeclampsia in Dutch families. Despite the...
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