Article
Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence.
Annals of surgery - 1 Nov 2005
Alvarez-Lobos Manuel, Arostegui Juan I, Sans Miquel, Tassies Dolors, Plaza Susana, Delgado Salvadora, Lacy Antonio M, Pique Josep M, Yagüe Jordi, Panés Julián
Abstract excerpt
OBJECTIVE: To study the predictive value of Nod2/CARD15 gene variants along with disease phenotypic characteristics for requirement of initial surgery and for surgical recurrence in Crohn's disease (CD). SUMMARY BACKGROUND DATA: Nod2/CARD15 gene variants play an important role in the susceptibility to CD. Studies of genotype-phenotype relationship suggest that these variants are associated with development of...
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