Article
Absence of primary integrase resistance mutations in HIV type 1-infected patients in Venezuela.
AIDS research and human retroviruses - 1 Aug 2010
Rangel Héctor R, Garzaro Domingo, Fabbro Rona, Martinez Nahir, Ossenkop John, Torres Jaime R, Gutiérrez Cristina R, Pujol Flor H
Abstract excerpt
The preexistence of mutations to integrase inhibitors in HIV-1-infected Venezuelan patients was evaluated. The integrase region of the HIV-1 genome was amplified by nested-PCR and sequenced in 57 isolates from both naive (n = 24) and treated patients who received protease and/or reverse transcriptase inhibitors (PI and RTI, n = 33), but were never exposed to integrase inhibitors. Only one primary integrase...
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