Article
Analysis of HIV type 1 protease and reverse transcriptase sequences from Venezuela for drug resistance-associated mutations and subtype classification: a UNAIDS study.
AIDS research and human retroviruses - 20 May 2001
Delgado E, León-Ponte M, Villahermosa M L, Cuevas M T, Deibis L, Echeverría G, Thomson M M, Pérez-Alvarez L, Osmanov S, Nájera R
Abstract excerpt
We report the first study on prevalence of antiretroviral drug-associated resistance mutations in Venezuela. Protease and reverse transcriptase (RT) coding regions were analyzed in DNA samples obtained from 100 HIV-1-infected individuals. Primary resistance mutations to RT inhibitors were identified in 26% of patients treated with these drugs. Transmission of HIV-1-resistant strains was detected in a drug-naive...
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