Article
Probing in vivo Mn2+ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2010
McNaughton Rebecca L, Reddi Amit R, Clement Matthew H S, Sharma Ajay, Barnese Kevin, Rosenfeld Leah, Gralla Edith Butler, Valentine Joan Selverstone, Culotta Valeria C, Hoffman Brian M
Abstract excerpt
Manganese is an essential transition metal that, among other functions, can act independently of proteins to either defend against or promote oxidative stress and disease. The majority of cellular manganese exists as low molecular-weight Mn(2+) complexes, and the balance between opposing "essential" and "toxic" roles is thought to be governed by the nature of the ligands coordinating Mn(2+). Until now, it has...
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