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Article

A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells.

Biochimica et biophysica acta - 1 Jan 2014

James Nicholas G, Digman Michelle A, Ross Justin A, Barylko Barbara, Wang Lei, Li Jinhui, Chen Yan, Mueller Joachim D, Gratton Enrico, Albanesi Joseph P, Jameson David M

Abstract excerpt

BACKGROUND: Dynamin 2 (Dyn2) is a ~100kDa GTPase that assembles around the necks of nascent endocytic and Golgi vesicles and catalyzes membrane scission. Mutations in Dyn2 that cause centronuclear myopathy (CNM) have been shown to stabilize Dyn2 polymers against GTP-dependent disassembly in vitro. Precisely timed regulation of assembly and disassembly is believed to be critical for Dyn2 function in membrane...

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Identifiers

PMID: 24016602
DOI: 10.1016/j.bbagen.2013.09.001
PMCID: PMC3859711

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