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Could genetic analysis be useful in reducing cerebrovascular risk in hypertensive subjects with hyperhomocysteinemia and patent foramen ovale? A 2-year follow-up study.

Microvascular research - 1 Dec 2010

Mazza Alberto, Montemurro Domenico, L'Erario Roberto, Chinaglia Mauro, Piergentili Cristian, Aggio Silvio, Zanon Francesco, Pastore Gianni, Zanier Ada, Grassetto Gaia, Zamboni Sergio, Rubello Domenico

Abstract excerpt

OBJECTIVES: Potential causes of cryptogenic cerebrovascular (CV) events are patent foramen ovale (PFO) and hyper homocysteinemia (H-Hcys), this latter a well-established risk factor for thrombosis particularly in the presence of mutation for the methylenetetrahydrofolate reductase (MTHFR) gene. This study investigated if in uncomplicated hypertensive subjects (HTs) with isolated PFO and H-Hcys, a different MTHFR...

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Identifiers

PMID: 20696177
DOI: 10.1016/j.mvr.2010.08.002

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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