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Comprehensive BRCA1 and BRCA2 mutation analyses and review of French Canadian families with at least three cases of breast cancer.

Familial cancer - 1 Dec 2010

Cavallone Luca, Arcand Suzanna L, Maugard Christine M, Nolet Serge, Gaboury Louis A, Mes-Masson Anne-Marie, Ghadirian Parviz, Provencher Diane, Tonin Patricia N

Abstract excerpt

Few studies have reported on the comprehensive BRCA1/2 mutation analyses of hereditary breast cancer (HBC) families of French Canadian descent. Here we report the investigation of 82 families with at least 3 cases of breast cancer evaluated for mutations by DNA sequencing and/or multiplex ligation-dependent probe amplification (MLPA) assay. DNA sequencing identified pathogenic mutations in 37 (45.1%) families, of...

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Identifiers

PMID: 20694749
DOI: 10.1007/s10689-010-9372-3

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BRCA1
BRCA2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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