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Article

Gamma-glutamyl carboxylase and its influence on warfarin dose.

Thrombosis and haemostasis - 1 Oct 2010

King Cristi R, Deych Elena, Milligan Paul, Eby Charles, Lenzini Petra, Grice Gloria, Porche-Sorbet Rhonda M, Ridker Paul M, Gage Brian F

Abstract excerpt

Via generation of vitamin K-dependent proteins, gamma-glutamyl carboxylase (GGCX) plays a critical role in the vitamin K cycle. Single nucleotide polymorphisms (SNPs) in GGCX, therefore, may affect dosing of the vitamin K antagonist, warfarin. In a multi-centered, cross-sectional study of 985 patients prescribed warfarin therapy, we genotyped for two GGCX SNPs (rs11676382 and rs12714145) and quantified their...

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Identifiers

PMID: 20694283
DOI: 10.1160/TH09-11-0763
PMCID: PMC2949522

Genes

GGCX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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