Article
Multiple mechanisms of methicillin resistance and improved methods for detection in clinical isolates of Staphylococcus aureus.
Antimicrobial agents and chemotherapy - 1 Apr 1991
de Lencastre H, Sá Figueiredo A M, Urban C, Rahal J, Tomasz A
Abstract excerpt
The mec gene of a number of clinical methicillin-resistant Staphylococcus aureus isolates exhibiting a variety of heterogeneous expression modes was selectively inactivated by allelic replacement mutagenesis. While the resistance level of each of the transformants was reduced, the methicillin MIC for these transformants was well above the MIC for susceptible laboratory strains of S. aureus and was similar to the...
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