Article
Multiple mechanisms of methicillin resistance and improved methods for detection in clinical isolates of Staphylococcus aureus.
Antimicrobial agents and chemotherapy - 1 Apr 1991
de Lencastre H, Sá Figueiredo A M, Urban C, Rahal J, Tomasz A
Abstract excerpt
The mec gene of a number of clinical methicillin-resistant Staphylococcus aureus isolates exhibiting a variety of heterogeneous expression modes was selectively inactivated by allelic replacement mutagenesis. While the resistance level of each of the transformants was reduced, the methicillin MIC...
Topics
- Clavulanic Acid
- Clavulanic Acids
- DNA Probes
- Methicillin Resistance
- Microbial Sensitivity Tests
- Nucleic Acid Hybridization
- Phenotype
- Staphylococcus aureus
- beta-Lactamases