Article
Histologic variations in juvenile polyp phenotype correlate with genetic defect underlying juvenile polyposis.
The American journal of surgical pathology - 1 Apr 2011
van Hattem Willem Arnout, Langeveld Danielle, de Leng Wendy W J, Morsink Folkert H, van Diest Paul J, Iacobuzio-Donahue Christine A, Giardiello Francis M, Offerhaus G Johan A, Brosens Lodewijk A A
Abstract excerpt
BACKGROUND: Juvenile polyps are distinct hamartomatous malformations of the gastrointestinal tract that may occur in the heritable juvenile polyposis syndrome (JPS) or sporadically. Histologically, juvenile polyps are characterized by a marked increase of the stromal cell compartment, but an epithelial phenotype has also been reported. JPS has an increased risk of colorectal cancer but sporadic juvenile polyps do...
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