Article
Adrenalectomy increases bicuculline-induced seizure sensitivity in long-sleep and short-sleep mice.
Pharmacology, biochemistry, and behavior - 1 Mar 1991
Bowers B J, Bosy T Z, Wehner J M
Abstract excerpt
Susceptibility to bicuculline-induced seizure onset and tonus was increased in LS and SS mice after adrenalectomy (ADX). Replacement with 10% corticosterone (CCS) in ADX animals resulted in a return to seizure latencies equal to those of sham-operated (SHAM) mice. In SS mice, dexamethasone (DEX) and cholesterol-control replacement was as effective as 10% CCS in returning seizure thresholds to SHAM values. In LS...
Topics
- Adrenal Glands
- Adrenalectomy
- Animals
- Bicuculline
- Body Weight
- Corticosterone
- Epilepsy
- Ethanol
- Genetic Predisposition to Disease
- Genotype
- Mice
- Mice, Inbred Strains