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Membrane Efflux and Influx Modulate both Multidrug Resistance and Virulence of <i>Klebsiella pneumoniae</i> in a <i>Caenorhabditis elegans</i> Model

3 Aug 2010

Abstract excerpt

Cross-resistance to cefoxitin (FOX), chloramphenicol (CMP), and quinolones (nalidixic acid [NAL]) related to a putative efflux system overexpression has recently been reported for Klebsiella pneumoniae. The potential impact of this multidrug resistance (MDR) on the virulence of K. pneumoniae was evaluated in the Caenorhabditis elegans model. For 2 of the 3 MDR clinical isolates studied, a significant increase in...

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PMID: 20679507
DOI: 10.1128/aac.01607-09

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