Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study.

Breast cancer research and treatment - 1 Feb 2011

Brasky Theodore M, Bonner Matthew R, Moysich Kirsten B, Ochs-Balcom Heather M, Marian Catalin, Ambrosone Christine B, Nie Jing, Tao Meng Hua, Edge Stephen B, Trevisan Maurizio, Shields Peter G, Freudenheim Jo L

Abstract excerpt

Chronic inflammation has been consistently associated with cancers of several sites, including the breast, and inhibition of inflammation through the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been inversely associated with risk. As NSAIDs bind with cyclooxygenase-2 (COX-2), genetic variation in COX-2 may influence breast cancer risk by affecting inflammatory response and response to NSAID use. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Aspirin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast

Share to Breast Neoplasms

Share to Clinical Trials, Phase II as Topic

Share to Cyclooxygenase 2

Share to DNA, Neoplasm

Share to Survival Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 20676755
DOI: 10.1007/s10549-010-1082-x
PMCID: PMC2992094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study.PMID 20676755Read ↗

Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk.Semantic proximity Read ↗

Association of the three common SNPs of cyclooxygenase-2 gene (rs20417, rs689466, and rs5275) with the susceptibility of breast cancer: an updated meta-analysis involving 34,590 subjects.Semantic proximity Read ↗

Associations between ALOX, COX, and CRP polymorphisms and breast cancer among Hispanic and non-Hispanic white women: The breast cancer health disparities study.Semantic proximity Read ↗

Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma.Semantic proximity Read ↗

Pharmacogenomics of cyclooxygenases.Semantic proximity Read ↗

A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control studySemantic proximity Read ↗

COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations.Semantic proximity Read ↗

COX2 genetic variation, NSAIDs, and advanced prostate cancer risk.Semantic proximity Read ↗

Causal relationship between anti-inflammatory drugs and cancer: a pan-cancer study with Mendelian randomizationSemantic proximity Read ↗

Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population.Semantic proximity Read ↗

Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma.Semantic proximity Read ↗

Nonsteroidal anti-inflammatory drugs and other analgesic use and bladder cancer in northern New England.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.