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Article

Predictive testing for Wilson's disease using tightly linked and flanking DNA markers.

Neurology - 1 Jul 1991

Farrer L A, Bowcock A M, Hebert J M, Bonné-Tamir B, Sternlieb I, Giagheddu M, St George-Hyslop P, Frydman M, Lössner J, Demelia L

Abstract excerpt

We studied DNA polymorphisms for five new chromosome 13 markers in 52 Wilson's disease (WD) families from Europe, North America, and the Middle East. There was significant evidence for linkage between the Wilson's disease locus (WND) and all the marker loci. Multilocus linkage analysis, using a genetic linkage map established from reference pedigrees, suggested that WND is most likely between D13S31 and D13S59,...

Topics

Chromosome Mapping
Genetic Linkage
Genetic Markers
Genotype
Hepatolenticular Degeneration
Humans
Pedigree
Predictive Value of Tests
Prenatal Diagnosis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2067662
DOI: 10.1212/wnl.41.7.992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2067662-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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