Article
Esterase D and retinoblastoma gene loci are tightly linked to Wilson's disease in Chinese pedigrees from Taiwan.
Human genetics - 1 Aug 1991
Chuang L M, Tai T Y, Wang T R, Chang Y C, Chen K H, Lin R S, Lin B J
Abstract excerpt
Wilson's disease (WD) is a rare autosomal recessive disorder and has been mapped to the long arm of chromosome 13 (q14.1). We have analyzed the segregation of esterase D (ESD) and retinoblastoma (RB) gene loci in ten families of Chinese WD subjects living in Taiwan. The polymorphic information content (PIC) for ESD and RB was 0.18 and 0.31, respectively. We confirmed a tight linkage between these loci and WD with...
Topics
- Alleles
- Carboxylesterase
- Carboxylic Ester Hydrolases
- China
- Chromosome Mapping
- Chromosomes, Human, Pair 13
- DNA
- Female
- Genes, Retinoblastoma
- Genetic Linkage
- Genotype