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Article

Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro

30 Jul 2010

Abstract excerpt

OBJECTIVE: miRNAs, which are non-coding RNAs, play a role in the pathogenesis of disease including OA. miRNA (miR)-34a is induced by p53, subsequently leading to cell apoptosis, which is one of the major factors in the pathogenesis of OA. The purpose of this study is to investigate the effect of silencing miR-34a on IL-1β-induced chondrocyte apoptosis in a rat OA model in vitro. METHODS: Locked nucleotide...

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PMID: 20675358
DOI: 10.1093/rheumatology/keq247

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