A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).

doi:10.1016/j.ajog.2010.05.026

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Article

A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).

American journal of obstetrics and gynecology - 1 Oct 2010

Romero Roberto, Friel Lara A, Velez Edwards Digna R, Kusanovic Juan Pedro, Hassan Sonia S, Mazaki-Tovi Shali, Vaisbuch Edi, Kim Chong Jai, Erez Offer, Chaiworapongsa Tinnakorn, Pearce Brad D, Bartlett Jacquelaine, Salisbury Benjamin A, Anant Madan Kumar, Vovis Gerald F, Lee Min Seob, Gomez Ricardo, Behnke Ernesto, Oyarzun Enrique, Tromp Gerard, Williams Scott M, Menon Ramkumar

Abstract excerpt

OBJECTIVE: We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM). STUDY DESIGN: A case-control study was conducted in patients with pPROM (225 mothers and 155 fetuses) and 599 mothers and 628 fetuses with a normal pregnancy; 190 candidate genes and 775 SNPs were studied. Single locus/haplotype...

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PMID: 20673868
DOI: 10.1016/j.ajog.2010.05.026
PMCID: PMC2989662

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