Article
Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - 1 Feb 2011
Edwards Digna R Velez, Romero Roberto, Kusanovic Juan Pedro, Hassan Sonia S, Mazaki-Tovi Shali, Vaisbuch Edi, Kim Chong Jai, Erez Offer, Chaiworapongsa Tinnakorn, Pearce Brad D, Bartlett Jacquelaine, Friel Lara A, Salisbury Benjamin A, Anant Madan Kumar, Vovis Gerald F, Lee Min Seob, Gomez Ricardo, Behnke Ernesto, Oyarzun Enrique, Tromp Gerard, Menon Ramkumar, Williams Scott M
Abstract excerpt
OBJECTIVE: To examine the association between maternal and fetal genetic variants and small-for-gestational-age (SGA). METHODS: A case-control study was conducted in patients with SGA neonates (530 maternal and 436 fetal) and controls (599 maternal and 628 fetal); 190 candidate genes and 775 SNPs were studied. Single-locus, multi-locus and haplotype association analyses were performed on maternal and fetal data...
Topics
- Adult
- Case-Control Studies
- Extracellular Matrix
- Female
- Fetal Development
- Fetal Growth Retardation