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FLT3 Mutations at Diagnosis and Relapse in Acute Myeloid Leukemia: Cytogenetic and Pathologic Correlations, Including Cuplike Blast Morphology

1 Aug 2010

Abstract excerpt

Abstract Context. —Acquired mutations in the fms-like tyrosine kinase 3 gene ( FLT3 ) adversely impact relapse risk after chemotherapy in patients with acute myeloid leukemia (AML). The FLT3 mutation status may differ at diagnosis and relapse, suggesting a potential role in chemoresistance, yet few reports have addressed the cytogenetic and pathologic correlates of FLT3 mutations in relapsed AML. Objectives. —To...

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PMID: 20670134
DOI: 10.5858/2009-0292-oa.1

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