Down-Regulation of Wee1 Kinase by a Specific Subset of microRNA in Human Sporadic Pituitary Adenomas

Abstract excerpt

CONTEXT: The tumorigenic mechanisms involved in pituitary adenomas, especially of nonfunctional pituitary adenomas (NFAs), remains unclear. Various cell cycle inhibitors have been found to be underexpressed in pituitary tumors; however, Wee1 kinase, a nuclear protein that delays mitosis and was recently recognized as a tumor suppressor gene, has not been previously investigated in pituitary tumors. OBJECTIVE: Our...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hedgehog Signaling Pathway Studies
• Share to Neurofibromatosis and Schwannoma Cases
• Share to Pituitary Gland Disorders and Treatments