Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia-induced down-modulation of PKCepsilon promotes trail-mediated apoptosis of tumor cells.

International journal of oncology - 1 Sept 2010

Gobbi Giuliana, Masselli Elena, Micheloni Cristina, Nouvenne Antonio, Russo Domenico, Santi Patrizia, Matteucci Alessandro, Cocco Lucio, Vitale Marco, Mirandola Prisco

Abstract excerpt

Tumor oxygen status is considered as a prognostic marker that impacts on malignant progression and outcome of tumor therapy. TNF-related apoptosis inducing ligand (TRAIL) plays a key role in cancer immunity, with potential applications in cancer therapy. Protein kinase C (PKC)epsilon, a transform...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-X Protein
Share to Cell Hypoxia
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Jurkat Cells

Share to K562 Cells

Share to Protein Kinase C-epsilon

Share to TNF-Related Apoptosis-Inducing Ligand

Source

Identifiers

PMID: 20664941
DOI: 10.3892/ijo_00000721

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20664941-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-induced down-modulation of PKCepsilon promotes trail-mediated apoptosis of tumor cells.PMID 20664941Read ↗

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth.Semantic proximity Read ↗

Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell TypesSemantic proximity Read ↗

Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, <i>RTP801</i> , Involved in ApoptosisSemantic proximity Read ↗

Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway.Semantic proximity Read ↗

Variable expression of protein kinase C epsilon in human melanoma cells regulates sensitivity to TRAIL-induced apoptosis.Semantic proximity Read ↗

Embelin downregulated cFLIP in breast cancer cell lines facilitate anti-tumor effect of IL-1β-stimulated human umbilical cord mesenchymal stem cellsSemantic proximity Read ↗

Hypoxia-inducible plasmid expressing both miSHP-1 and HO-1 for the treatment of ischemic diseaseSemantic proximity Read ↗

Change in TNF- <i>α</i> Receptor Expression Is a Relevant Event in Doxorubicin-Induced H9c2 Cardiomyocyte Cell DeathSemantic proximity Read ↗

Timing and Expression Level of Protein Kinase Cε Regulate the Megakaryocytic Differentiation of Human CD34 CellsSemantic proximity Read ↗

PKCϵ controls protection against TRAIL in erythroid progenitorsSemantic proximity Read ↗

Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxiaSemantic proximity Read ↗

Caveolin‐1 promotes resistance to chemotherapy‐induced apoptosis in Ewing's sarcoma cells by modulating PKCα phosphorylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.