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Article

Maternal trichloroethylene exposure and metabolic gene polymorphisms may interact during fetal cardiovascular malformation.

Reproductive toxicology (Elmsford, N.Y.) - 1 Dec 2021

Liu Zhen, Wang Meixian, Yu Ping, Li Xiaohong, Lin Yuan, Duan Yinghong, Tian Yan, Zhu Jun, Deng Ying, Li Nana

Abstract excerpt

This study aimed to analyze the potential association between trichloroethylene (TCE) exposure and congenital heart disease (CHD) and to explore the effect of metabolic enzyme gene polymorphisms on heart development. A multicenter case-control study was conducted. The trichloroethylene concentrations were measured by UPLC-MSMS in urine. Fourteen SNPs in the GSTA1, GSTP1, MPO, NAT1, NAT2, CYP1A1, CYP1A2, CYP2E1...

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PMID: 34555461
DOI: 10.1016/j.reprotox.2021.09.010

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