Article
Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.
PLoS genetics - 22 Jul 2010
Stacey Simon N, Sulem Patrick, Zanon Carlo, Gudjonsson Sigurjon A, Thorleifsson Gudmar, Helgason Agnar, Jonasdottir Aslaug, Besenbacher Soren, Kostic Jelena P, Fackenthal James D, Huo Dezheng, Adebamowo Clement, Ogundiran Temidayo, Olson Janet E, Fredericksen Zachary S, Wang Xianshu, Look Maxime P, Sieuwerts Anieta M, Martens John W M, Pajares Isabel, Garcia-Prats Maria D, Ramon-Cajal Jose M, de Juan Ana, Panadero Angeles, Ortega Eugenia, Aben Katja K H, Vermeulen Sita H, Asadzadeh Fatemeh, van Engelenburg K C Anton, Margolin Sara, Shen Chen-Yang, Wu Pei-Ei, Försti Asta, Lenner Per, Henriksson Roger, Johansson Robert, Enquist Kerstin, Hallmans Göran, Jonsson Thorvaldur, Sigurdsson Helgi, Alexiusdottir Kristin, Gudmundsson Julius, Sigurdsson Asgeir, Frigge Michael L, Gudmundsson Larus, Kristjansson Kristleifur, Halldorsson Bjarni V, Styrkarsdottir Unnur, Gulcher Jeffrey R, Hemminki Kari, Lindblom Annika, Kiemeney Lambertus A, Mayordomo Jose I, Foekens John A, Couch Fergus J, Olopade Olufunmilayo I, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Rafnar Thorunn, Johannsson Oskar T, Stefansson Kari
Abstract excerpt
We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes. We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily so in other...