Article
Recombination and mutation during long-term gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size, and minimal age.
Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2001
Falush D, Kraft C, Taylor N S, Correa P, Fox J G, Achtman M, Suerbaum S
Abstract excerpt
The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of strains isolated sequentially at a mean interval of 1.8 years from 26 individuals. Several isolates had acquired small mosaic segments from other H. pylori or point mutations. The maximal mutation rate, the import size,...
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