Article
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
Human molecular genetics - 1 Nov 2010
O'Seaghdha Conall M, Yang Qiong, Glazer Nicole L, Leak Tennille S, Dehghan Abbas, Smith Albert V, Kao W H Linda, Lohman Kurt, Hwang Shih-Jen, Johnson Andrew D, Hofman Albert, Uitterlinden Andre G, Chen Yii-Der Ida, Brown Edward M, Siscovick David S, Harris Tamara B, Psaty Bruce M, Coresh Josef, Gudnason Vilmundur, Witteman Jacqueline C, Liu Yong Mei, Kestenbaum Bryan R, Fox Caroline S, Köttgen Anna
Abstract excerpt
Serum calcium levels are tightly regulated. We performed genome-wide association studies (GWAS) in population-based studies participating in the CHARGE Consortium to uncover common genetic variations associated with total serum calcium levels. GWAS of serum calcium concentrations was performed in 20 611 individuals of European ancestry for ∼2.5 million genotyped and imputed single-nucleotide polymorphisms (SNPs)....
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