Article
Development and application of a broadly sensitive dried-blood-spot-based genotyping assay for global surveillance of HIV-1 drug resistance.
Journal of clinical microbiology - 1 Sept 2010
Yang Chunfu, McNulty Amanda, Diallo Karidia, Zhang Jing, Titanji Boghuma, Kassim Sidibe, Wadonda-Kabondo Nellie, Aberle-Grasse John, Kibuka Tabitha, Ndumbe Peter M, Vedapuri Shanmugam, Zhou Zhiyong, Chilima Benson, Nkengasong John N
Abstract excerpt
As antiretroviral therapy (ART) is scaled up in resource-limited countries, surveillance for HIV drug resistance (DR) is vital to ensure sustained effectiveness of first-line ART. We have developed and applied a broadly sensitive dried-blood-spot (DBS)-based genotyping assay for surveillance of HIV-1 DR in international settings. In 2005 and 2006, 171 DBS samples were collected under field conditions from newly...
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