Article
Short rare hTERT-VNTR2-2nd alleles are associated with prostate cancer susceptibility and influence gene expression.
BMC cancer - 26 Jul 2010
Yoon Se-Lyun, Jung Se-Il, Do Eun-Ju, Lee Se-Ra, Lee Sang-Yeop, Chu In-Sun, Kim Wun-Jae, Jung Jaeil, Kim Choung Soo, Cheon Sang-Hyeon, Leem Sun-Hee
Abstract excerpt
BACKGROUND: The hTERT (human telomerase reverse transcriptase) gene contains five variable number tandem repeats (VNTR) and previous studies have described polymorphisms for hTERT-VNTR2-2nd. We investigated how allelic variation in hTERT-VNTR2-2nd may affect susceptibility to prostate cancer. METHODS: A case-control study was performed using DNA from 421 cancer-free male controls and 329 patients with prostate...
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