Article
Expression and Genetic Variation in Neuroendocrine Signaling Pathways in Lethal and Nonlethal Prostate Cancer among Men Diagnosed with Localized Disease.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2017
Lu Donghao, Carlsson Jessica, Penney Kathryn L, Davidsson Sabina, Andersson Swen-Olof, Mucci Lorelei A, Valdimarsdóttir Unnur, Andrén Ove, Fang Fang, Fall Katja
Abstract excerpt
Background: Recent data suggest that neuroendocrine signaling pathways may play a role in the progression of prostate cancer, particularly for early-stage disease. We aimed to explore whether expression of selected genes in the adrenergic, serotoninergic, glucocorticoid, and dopaminergic pathways differs in prostate tumor tissue from men with lethal disease compared with men with nonlethal disease.Methods: On the...
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