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Article

The Impact of TSC-1 and -2 Mutations on Response to Therapy in Malignant PEComa: A Multicenter Retrospective Analysis.

Genes - 24 Oct 2022

Liu Lawrence, Dehner Carina, Grandhi Nikhil, Lyu Yang, Borcherding Dana C, Chrisinger John S A, Zhang Xiao, Luo Jingqin, Tao Yu, Parkes Amanda, Bui Nam Q, Davis Elizabeth J, Milhem Mohammed M, Monga Varun, Weiss Mia, Tine Brian Van, Hirbe Angela C

Abstract excerpt

BACKGROUND: Perivascular epithelioid cell neoplasms (PEComas) are a diverse family of mesenchymal tumors with myomelanocytic differentiation that disproportionately affect women and can be associated with tuberous sclerosis (TS). Although mTOR inhibition is widely used as first-line treatment, it is unclear what genomic alterations exist in these tumors and how they influence the response to therapy. METHODS:...

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PMID: 36360169
DOI: 10.3390/genes13111932
PMCID: PMC9689779

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