Article
Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia.
Circulation. Cardiovascular genetics - 1 Feb 2012
Johansen Christopher T, Wang Jian, McIntyre Adam D, Martins Rebecca A, Ban Matthew R, Lanktree Matthew B, Huff Murray W, Péterfy Miklós, Mehrabian Margarete, Lusis Aldons J, Kathiresan Sekar, Anand Sonia S, Yusuf Salim, Lee Ann-Hwee, Glimcher Laurie H, Cao Henian, Hegele Robert A
Abstract excerpt
BACKGROUND: Rare variant accumulation studies can implicate genes in disease susceptibility when a significant burden is observed in patients versus control subjects. Such analyses might be particularly useful for candidate genes that are selected based on experiments other than genome-wide association studies (GWAS). We sought to determine whether rare variants in non-GWAS candidate genes identified from mouse...
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