Article
Two distinct mechanisms regulate recruitment of murine leukemia virus envelope protein to retroviral assembly sites.
Virology - 30 Sept 2010
Lucas Tiffany M, Lyddon Terri D, Grosse Sarah A, Johnson Marc C
Abstract excerpt
The cytoplasmic tail domain (CTD) of retroviral envelope (Env) proteins has been implicated in modulating Env incorporation into viral particles. We generated a panel of murine leukemia virus (MLV) Env mutants and analyzed their ability to be recruited to human immunodeficiency virus-1 (HIV-1) assembly sites. Surprisingly, the entire CTD was dispensable for recruitment to assembly sites, but a mutation that...
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