Article
HIV-1 subtype B and C integrase enzymes exhibit differential patterns of resistance to integrase inhibitors in biochemical assays.
AIDS (London, England) - 10 Sept 2010
Bar-Magen Tamara, Donahue Daniel A, McDonough Emily I, Kuhl Björn D, Faltenbacher Verena H, Xu Hongtao, Michaud Veronique, Sloan Richard D, Wainberg Mark A
Abstract excerpt
BACKGROUND: Because of high intersubtype HIV-1 genetic variability, it has been shown that subtype-specific patterns of resistance to antiretroviral drugs exist. We wished to ascertain whether this might be true for integrase inhibitors. METHODS: We compared the susceptibility of subtype B and C HIV-1 integrase enzymes, harboring the previously reported resistance mutations E92Q, N155H, and E92Q/N155H, to...
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