Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA polymorphisms in the controlling region of the human haptoglobin genes: a molecular explanation for the haptoglobin 2-1 modified phenotype.

American journal of human genetics - 1 Jul 1991

Maeda N

Abstract excerpt

A haptoglobin 2-1 modified (Hp2-1mod) phenotype results when the amount of Hp2 polypeptide synthesized in Hp2/Hp1 heterozygotes is less than that of Hp1 polypeptide. Cloned Hp2 DNA from an individual with the Hp2-1mod phenotype is here shown to have a C in place of the normal A at nucleotide position -61 in one of the interleukin-6 (IL-6) responsive elements of the haptoglobin promoter region. Direct sequencing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterozygote

Share to Molecular Sequence Data

Share to Phenotype

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2063867
PMCID: PMC1683214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA polymorphisms in the controlling region of the human haptoglobin genes: a molecular explanation for the haptoglobin 2-1 modified phenotype.PMID 2063867Read ↗

A base substitution in the promoter associated with the human haptoglobin 2-1 modified phenotype decreases transcriptional activity and responsiveness to interleukin-6 in human hepatoma cells.Semantic proximity Read ↗

Polymorphism of human haptoglobin and its clinical importanceSemantic proximity Read ↗

Biological and clinical significance of haptoglobin polymorphism in humansSemantic proximity Read ↗

A novel I247T missense mutation in the haptoglobin 2 beta-chain decreases the expression of the protein and is associated with ahaptoglobinemia.Semantic proximity Read ↗

Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR.Semantic proximity Read ↗

Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection.Semantic proximity Read ↗

TaqMan-based real-time PCR for genotyping common polymorphisms of haptoglobin (HP1 and HP2).Semantic proximity Read ↗

The haptoglobin-gene deletion responsible for anhaptoglobinemia.Semantic proximity Read ↗

The haptoglobin 2-2 phenotype affects serum markers of iron status in healthy males.Semantic proximity Read ↗

Association between Cys282Tyr missense mutation and haptoglobin phenotype polymorphism in patients with chronic hepatitis C.Semantic proximity Read ↗

Haptoglobin phenotype and risk of cervical neoplasia: a case-control study.Semantic proximity Read ↗

The T----C substitution at -198 of the A gamma-globin gene associated with the British form of HPFH generates overlapping recognition sites for two DNA-binding proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.