DNA polymorphisms in the controlling region of the human haptoglobin genes: a molecular explanation for the haptoglobin 2-1 modified phenotype.

Article

DNA polymorphisms in the controlling region of the human haptoglobin genes: a molecular explanation for the haptoglobin 2-1 modified phenotype.

American journal of human genetics - 1 Jul 1991

Maeda N

Abstract excerpt

A haptoglobin 2-1 modified (Hp2-1mod) phenotype results when the amount of Hp2 polypeptide synthesized in Hp2/Hp1 heterozygotes is less than that of Hp1 polypeptide. Cloned Hp2 DNA from an individual with the Hp2-1mod phenotype is here shown to have a C in place of the normal A at nucleotide posi...

Topics

Base Sequence
DNA
Genotype
Haptoglobins
Heterozygote
Humans
Molecular Sequence Data
Phenotype
Polymorphism, Genetic
Promoter Regions, Genetic

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