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Article

8q24 allelic imbalance and MYC gene copy number in primary prostate cancer.

Prostate cancer and prostatic diseases - 1 Sept 2010

Chen H, Liu W, Roberts W, Hooker S, Fedor H, DeMarzo A, Isaacs W, Kittles R A

Abstract excerpt

Four independent regions within 8q24 near the MYC gene are associated with risk for prostate cancer (Pca). Here, we investigated allelic imbalance (AI) at 8q24 risk variants and MYC gene DNA copy number (CN) in 27 primary Pcas. Heterozygotes were observed in 24 of 27 patients at one or more 8q24 markers and 27% of the loci exhibited AI in tumor DNA. The 8q24 risk alleles were preferentially favored in the tumors....

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Source

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Identifiers

PMID: 20634801
DOI: 10.1038/pcan.2010.20
PMCID: PMC3963483

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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