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Article

Evolution of new enzymatic function by structural modulation of cysteine reactivity in Pseudomonas fluorescens isocyanide hydratase.

The Journal of biological chemistry - 17 Sept 2010

Lakshminarasimhan Mahadevan, Madzelan Peter, Nan Ruth, Milkovic Nicole M, Wilson Mark A

Abstract excerpt

Isocyanide (formerly isonitrile) hydratase (EC 4.2.1.103) is an enzyme of the DJ-1 superfamily that hydrates isocyanides to yield the corresponding N-formamide. In order to understand the structural basis for isocyanide hydratase (ICH) catalysis, we determined the crystal structures of wild-type...

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Identifiers

PMID: 20630867
DOI: 10.1074/jbc.M110.147934
PMCID: PMC2937996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20630867-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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