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Article

Lymphotoxin-β Interacts with Methylated EGFR to Mediate Acquired Resistance to Cetuximab in Head and Neck Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2017

Hsu Dennis Shin-Shian, Hwang Wei-Lun, Yuh Chiou-Hwa, Chu Chen-Hsi, Ho Yang-Hui, Chen Pon-Bo, Lin Han-Syuan, Lin Hua-Kuo, Wu Shih-Pei, Lin Chih-Yi, Hsu Wen-Hao, Lan Hsin-Yi, Wang Hsiao-Jung, Tai Shyh-Kuan, Hung Mien-Chie, Yang Muh-Hwa

Abstract excerpt

Purpose: In head and neck squamous cell carcinoma (HNSCC), the incidence of RAS mutation, which is the major cause of cetuximab resistance, is relatively rare compared with the other types of cancers, and the mechanism mediating acquired resistance is unclear compared with the driver gene mutation-mediated de novo resistance. Here, we investigated the driver gene mutation-independent mechanism for cetuximab...

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Share to Cetuximab
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Protein-Arginine N-Methyltransferases

Share to Snail Family Transcription Factors

Share to Squamous Cell Carcinoma of Head and Neck

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Source

Identifiers

PMID: 28196873
DOI: 10.1158/1078-0432.CCR-16-1955

Genes

EGFR
PRMT1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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